منابع مشابه
Cytochrome P450 2D6 as a model antigen.
Cytochrome P450 2D6 (CYP2D6) has been identified as the major autoantigen in type 2 autoimmune hepatitis (AIH). However, because of a lack of appropriate animal models, the etiology of AIH is still poorly understood. We generated a mouse model for AIH using the human CYP2D6 as a triggering molecule for autoimmunity. We infected wild-type FVB mice with an adenovirus expressing human CYP2D6 (Ad-2...
متن کاملOxidation of Methoxyphenethylamines by Cytochrome P450 2D6
Cytochrome P450 (P450) 2D6 is involved in the oxidation of a large fraction ( 30%) of drugs used by humans and also catalyzes the O-demethylation of the model substrates 3and 4-methoxyphenethylamine followed by subsequent ring hydroxylation to dopamine. Burst kinetics were not observed; rate-limiting step(s) must occur prior to product formation. Rates of reduction of ferric P450 2D6 were stimu...
متن کاملPharmacogenetics of Cytochrome P450 2D6: A Translational Medicine Perspective
With rapid scientific advances in the postgenomic era, pharmacogenomics has developed into an important area of translational medicine research. Pharmacogenetics studies the variability in drug response between different patient genotypes. By using patient genomic information, this bench-to-bedside research approach aims to develop more effective targeting of drug therapy in clinical practice. ...
متن کاملThe cytochrome P450 2D6*10 genetic polymorphism alters postoperative analgesia.
The present study was aimed to investigate the effects of the cytochrome P450 (CYP) 2D6*10 genetic polymorphism on postoperative patient-controlled morphine usage. A total of 114 patients were selected, and 102 patients completed the study. Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used to determine the CYP2D6*10 genotype, and patients were categori...
متن کاملRapid and reliable method for cytochrome P450 2D6 genotyping.
BACKGROUND Single-nucleotide polymorphisms and single-base deletions within the cytochrome P450 2D6 (CYP2D6) gene have been associated with a poor metabolizer (PM) phenotype and display a frequency of 7-10% in the Caucasian population. METHODS We developed a reliable and rapid procedure to identify five major PM-associated mutations (CYP2D6*4, *7, and *8) and deletions (CYP2D6*3 and *6) by re...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2009
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32832e0e97